Gasdermin D opens the way for NETs

Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflam...

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Bibliographic Details
Published inNature reviews. Rheumatology Vol. 14; no. 12; pp. 690 - 692
Main Authors Spel, Lotte, Martinon, Fabio
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.12.2018
Nature Publishing Group
Subjects
631/250/2504/223/1699
631/80/82
692/4023/1670
692/420/256
Analysis
Biochemistry
Care and treatment
Cell death
DNA
Immune response
Inflammation
Inflammatory diseases
Medicine
Medicine & Public Health
Neutrophils
News & Views
news-and-views
Pathogenic microorganisms
Proteins
Pyroptosis
Rheumatology
Universities and colleges
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Summary:Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.
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ISSN:1759-4790
1759-4804
DOI:10.1038/s41584-018-0124-3