Public health risk due to aflatoxin and fumonisin contamination in rice in the Mekong Delta, Vietnam

• Published in: Food safety and risk Vol. 10; no. 1; pp. 4 - 13
• Main Authors: Phan, Lien Thi Kim, De Saeger, Sarah, Eeckhout, Mia, Jacxsens, Liesbeth
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2023; Springer Nature B.V; BMC
• Subjects: Adolescents; Adults; Aflatoxins; Age groups; Carcinogens; Chemistry; Chemistry and Materials Science; Children; Consumption; Contamination; Evaluation; Exposure; Food contamination & poisoning; Food Science; Fumonisins; Health risk assessment; Health risks; Liver cancer risk; Lower bounds; Margin of exposure; Mycotoxins; Older people; Probabilistic risk assessment; Public health; Rice; Rice consumption; Risk assessment; Total aflatoxins and fumonisins, Mekong Delta; Upper bounds; Vietnam; Rice consumption; Total aflatoxins and fumonisins, Mekong Delta; Liver cancer risk; Margin of exposure
• ISSN: 2731-9245; 2731-9245; 2196-2804
• DOI: 10.1186/s40550-023-00104-0

Mycotoxin contamination in rice can lead to a health risk for consumers. In this study, the health risk among different age groups of Vietnamese population in the Mekong Delta, Vietnam was evaluated through rice consumption. Total aflatoxins (AFs) and fumonisins (FBs) in raw rice samples ( n  = 50) were analyzed using an ELISA method. A survey ( n  = 155) was used to collect data on rice consumption and consumer practices for the evaluation of mycotoxin exposure. Results showed that the frequency of AFs and FBs contamination was 60 and 74% with the average concentrations in raw rice ranging from 1.88–4.00 ng/g and 227–290 ng/g from the lower bound (LB) to the upper bound (UB), respectively. The average AFs exposure due to rice consumption was estimated from 0.81 to 2.44 ng/kg bw/day at scenarios LB – UB with the medium bound (MB) of 2.10, 1.60, 1.92 and 1.23 ng/kg bw/day for children, adolescents, adults and elderly, respectively. These values ranged from 343 to 724 ng/kg bw/day with respect to FBs (scenarios LB - UB), which are below the provisional maximum tolerable daily intakes (PMTDI) value (2000 ng/kg bw/day). The margin of exposure (MoE) to AFs ranged from 160 to 1585,179-2669,149–2175 and 206–3480 for children, adolescent, adults and elderly, respectively from UB - LB, indicating a high health risk for this carcinogenic hazard since the values are so lower than 10,000 (safe limit). However, for FBs, MoE value ranged from 105 to 575 (UB-LB) for all groups, which are higher compared to 100 (safe limit), indicating no risk for public health. The mean cancer risk due to estimated AFs exposure at LB - UB was 0.05–0.13 cases/year/100,000 individuals with MB of 0.08–0.13 cases/year/100,000 people for all four age groups. This study provides new insights into probabilistic risk assessment and potential health impact of mycotoxins in rice in the Mekong Delta, Vietnam.