Extensive Radiation-Induced Heart Disease in an Adult Patient Treated for Lymphoma as a Child

• Published in: Canadian journal of cardiology Vol. 27; no. 3; pp. 390.e1 - 390.e4
• Main Authors: Poulin, Frédéric, MD, FRCP, Semionov, Alexandre, MD, FRCP, Roméo, Philippe, MD, FRCP, Demers, Philippe, MD, MSc, FRCP, Pressacco, Josephine, MD, PhD, FRCP, Basmadjian, Arsène, MD, MSc, FRCP
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2011
• Subjects: Adult; Biopsy, Needle; Cardiac Catheterization; Cardiovascular; Child; Disease Progression; Fatal Outcome; Heart Diseases - etiology; Heart Diseases - physiopathology; Heart Diseases - surgery; Hodgkin Disease - diagnosis; Hodgkin Disease - radiotherapy; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Postoperative Complications - physiopathology; Radiation Injuries - diagnosis; Radiation Injuries - therapy; Radiotherapy Dosage; Radiotherapy, High-Energy - adverse effects; Risk Assessment; Severity of Illness Index; Time Factors; Tomography, X-Ray Computed
• ISSN: 0828-282X; 1916-7075
• DOI: 10.1016/j.cjca.2010.12.048

Abstract Cardiovascular complications are the second leading cause of late mortality in survivors of Hodgkin's lymphoma (HL) exposed to mediastinal radiotherapy. Symptomatic cardiac disease following classic thoracic irradiation for HL is reported in 10%-30% of patients at 5-10 years of follow-up. We present the case of a 44-year-old man with a history of left cervical nodular lymphocyte predominant HL treated at childhood with 40 Gy extended field thoracic irradiation (Mantle) who presented with mixed aortic and mitral valve disease, coronary artery stenosis, myocardial and aortic calcifications, and mediastinal fibrosis. Despite extensive cardiac surgery, the postoperative course was complicated and resulted in the patient's death. We review herein the typical cardiac involvement related to mediastinal radiotherapy and the controversies surrounding its surgical approach.