Fractalkine receptor polymorphism and chronic tonsillitis

• Published in: European archives of oto-rhino-laryngology Vol. 271; no. 7; pp. 2045 - 2048
• Main Authors: Babakurban, Seda Turkoglu, Erbek, Selim S., Terzi, Yunus Kasim, Arslan, Fatih, Sahin, Feride I.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2014
• Subjects: Adolescent; Case-Control Studies; Child, Preschool; Chronic Disease; Cross-Sectional Studies; CX3C Chemokine Receptor 1; Female; Gene Frequency; Genotype; Head and Neck Surgery; Humans; Infant; Male; Medicine; Medicine & Public Health; Miscellaneous; Neurosurgery; Otorhinolaryngology; Polymorphism, Single Nucleotide - genetics; Prospective Studies; Receptors, Chemokine - genetics; Tonsillitis - genetics; Young Adult; Chronic tonsillitis; Genotype; CR1; Fractalkine receptor (CX; Polymorphism
• ISSN: 0937-4477; 1434-4726; 1434-4726
• DOI: 10.1007/s00405-014-2908-7

The objective of this study is to examine whether there is an association of fractalkine gene receptor polymorphisms with chronic tonsillitis. This is a cross-sectional study in the setting of a tertiary referral center. The study group included 79 patients with chronic tonsillitis and 76 controls without history of chronic tonsillitis. Genotypes were identified by restriction fragment length polymorphism analyses after polymerase chain reaction. c.745G>A (V249I) single nucleotide polymorphism and the frequencies of the G and A alleles did not differ in the patient and control groups ( p  = 0.363; p  = 0.743, respectively). c.839C>T (T280M) single nucleotide polymorphism was found to be higher in controls than in the patients with chronic tonsillitis ( p  < 0.001). Consistent with this result, T allele frequency was higher in controls than in the patients with chronic tonsillitis ( p  < 0.001). In this study, we suggested that fractalkine gene receptor c.839C>T (T280M) single nucleotide polymorphism could be associated with a reduced risk of chronic tonsillitis.