Dose-response relationship between urinary polycyclic aromatic hydrocarbons metabolites and urinary 8-hydroxy-2′-deoxyguanosine in a Chinese general population

• Published in: Chemosphere (Oxford) Vol. 174; pp. 506 - 514
• Main Authors: Sun, Huizhen, Hou, Jian, Zhou, Yun, Yang, Yuqing, Cheng, Juan, Xu, Tian, Xiao, Lili, Chen, Weihong, Yuan, Jing
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2017
• Subjects: 8-Hydroxy-2′-deoxyguanosine; Adult; Aged; Asian Continental Ancestry Group; Biomarkers - urine; body mass index; children; Chromatography, High Pressure Liquid; Cohort Studies; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; dose response; Dose-response relationship; Dose-Response Relationship, Drug; Environmental Monitoring; Environmental Pollutants - metabolism; Environmental Pollutants - urine; Female; Gas Chromatography-Mass Spectrometry; high performance liquid chromatography; Humans; Male; metabolites; Middle Aged; Multiple linear regression analysis; Obesity; Obesity - urine; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - metabolism; Polycyclic Aromatic Hydrocarbons - urine; regression analysis; Obesity; 1-OHPYR; 2-OHPHE; WHtR; 2-OHFLU; 9-OHPHE; 9-OHFLU; WC; 1-OHPHE; 4-OHPHE; 8-Hydroxy-2′-deoxyguanosine; Polycyclic aromatic hydrocarbons; Multiple linear regression analysis; 2-OHNAP; Dose-response relationship; Cre; OH-PAHs; 3-OHPHE; 95% CI; HPLC; 1-OHNAP; BMI; 8-OHdG
• ISSN: 0045-6535; 1879-1298; 1879-1298
• DOI: 10.1016/j.chemosphere.2017.01.104

Association of exposure to polycyclic aromatic hydrocarbons (PAHs) with increased urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) formation has been reported in occupational population and children. However, studies on the association between them in general population are limited. A total of 1864 eligible subjects from the baseline Wuhan participants of the Wuhan-Zhuhai Cohort Study (n = 3053) were included in this study, after excluding individuals with certain disease and missing data on urinary monohydroxy PAHs (OH-PAHs) and 8-OHdG levels. Urinary monohydroxy PAHs and 8-OHdG levels were measured by gas chromatography-mass spectrometry and high performance liquid chromatography-electrochemical detection, respectively. Association of urinary OH-PAHs with urinary 8-OHdG was analyzed by multiple linear regression analysis. We found a dose-dependent relationship between urinary PAHs metabolites and urinary 8-OHdG (p < 0.05 for all). Furthermore, more evidence for the association of total concentrations of urinary OH-PAHs with 8-OHdG levels were observed in individuals with normal body mass index or central obesity (p < 0.01 for all). There was a dose-dependent relationship between urinary OH-PAHs levels and urinary 8-OHdG levels among a general Chinese population. Exposure to background PAHs may have a greater influence on urinary 8-OHdG levels in individuals with central obesity. [Display omitted] •Urinary OH-PAHs were associated with a dose-dependent increase in urinary 8-OHdG.•Urinary OH-PAHs had stronger association with urinary 8-OHdG in nonobese adults.•Urinary 8-OHdG was prominently affected by PAH exposure in central obesity adults.