Acute Myelogenous Leukemia Complicated by Acute Necrotizing Ulcerative Gingivitis Due to Aspergillus terreus

Infections caused by Aspergillus terreus are rare but have been associated with a poor outcome in immunocompromised patients due to frequent resistance to conventional antifungal therapy. This report describes a case of a woman who developed acute necrotizing ulcerative gingivitis (ANUG) due to A. t...

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Bibliographic Details
Published inLeukemia & lymphoma Vol. 44; no. 4; pp. 709 - 713
Main Authors Khoury, H., Poh, C.F., Williams, M., Lavoie, J.C., Nevill, T.J.
Format Journal Article
LanguageEnglish
Published United States Informa UK Ltd 01.01.2003
Taylor & Francis
Subjects
Acute Myelogenous Leukemia
Acute Necrotizing Ulcerative Gingivitis
Adolescent
Adult
Aged
Aspergillus - metabolism
Aspergillus Terreus
Child
Child, Preschool
Female
Gingivitis, Necrotizing Ulcerative - complications
Gingivitis, Necrotizing Ulcerative - microbiology
Humans
Infant
Itraconazole
Itraconazole - pharmacology
Leukemia, Myeloid, Acute - complications
Male
Middle Aged
Treatment Outcome
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Summary:Infections caused by Aspergillus terreus are rare but have been associated with a poor outcome in immunocompromised patients due to frequent resistance to conventional antifungal therapy. This report describes a case of a woman who developed acute necrotizing ulcerative gingivitis (ANUG) due to A. terreus during induction chemotherapy for acute myelogenous leukemia. She initially failed to respond to treatment with amphotericin B but the infection resolved following the introduction of oral itraconazole. Opportunistic infections caused by A. terreus are an emerging problem and can be associated with a high mortality rate. Early microbiological diagnosis is critical since resistance to amphotericin B is likely and itraconazole appears to be an effective treatment for this infection.
Bibliography:ObjectType-Case Study-2
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ISSN:1042-8194
1029-2403
DOI:10.1080/1042819031000060573