Association of vegetable and fruit intake with gastric cancer risk among Japanese: a pooled analysis of four cohort studies

• Published in: Annals of oncology Vol. 25; no. 6; pp. 1228 - 1233
• Main Authors: Shimazu, T., Wakai, K., Tamakoshi, A., Tsuji, I., Tanaka, K., Matsuo, K., Nagata, C., Mizoue, T., Inoue, M., Tsugane, S., Sasazuki, S., Sasazuki, Shizuka, Tsugane, Shoichiro, Inoue, Manami, Iwasaki, Motoki, Otani, Tetsuya, Sawada, Norie, Shimazu, Taichi, Yamaji, Taiki, Tsuji, Ichiro, Tsubono, Yoshitaka, Nishino, Yoshikazu, Tamakoshi, Akiko, Matsuo, Keitaro, Ito, Hidemi, Wakai, Kenji, Nagata, Chisato, Mizoue, Tetsuya, Tanaka, Keitaro
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2014; Oxford University Press
• Subjects: Asian Continental Ancestry Group; Biological and medical sciences; Cohort Studies; Diet; Diet Surveys; epidemiology; Female; Fruit; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Incidence; Male; Medical sciences; pooled analysis; Proportional Hazards Models; prospective studies; Risk Factors; stomach neoplasms; Stomach Neoplasms - epidemiology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surveys and Questionnaires; Tumors; Vegetables; Asia; Japan; epidemiology; pooled analysis; stomach neoplasms; vegetables; fruit; prospective studies; Human; Vegetables; Fruit; Malignant tumor; Stomach cancer; Epidemiology; Feeding; Prospective; Diet; Cohort study; Risk factor; Digestive diseases; Public health; Cancer; Gastric disease
• ISSN: 0923-7534; 1569-8041
• DOI: 10.1093/annonc/mdu115

Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. In an analysis of original data from four population-based prospective cohort studies encompassing 191 232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. During 2 094 428 person-years of follow-up, 2995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77–1.03; P for trend = 0.13) among men and 0.83 (0.67–1.03; P for trend = 0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63–0.97; P for trend = 0.02) among men. This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.