Hydrogel–nanoparticle hybrids for biomedical applications: principles and advantages

• Published in: Nanomedicine (London, England) Vol. 16; no. 2; pp. 81 - 84
• Main Authors: Sulaiman, Nur Shahirah, Hamzah, Nurasyikin, Zakaria, Siti Fatimah, Che Othman, Siti Fairuz, Mohamed Suffian, Izzat Fahimuddin
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.01.2021
• Subjects: biomedical; Brain cancer; Breast cancer; Cancer therapies; Drug delivery systems; Drugs; hybrid; hydrogel; Hydrogels; Methods; nanoparticle-hydrogel hybrid; Nanoparticles; Pharmaceutical industry; Polymers; treatment; treatment; hybrid; nanoparticles; nanoparticle-hydrogel hybrid; hydrogel; biomedical
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2020-0420

Hydrogel-nanoparticle hybrids The versatility of hydrogels and their improvisation Hydrogels have sparked interest among researchers in the field of drug delivery as they provide a convenient approach to deliver drugs efficiently. Hydrophobic drugs play a critical role in the pharmaceutical industry, especially in cancer therapy where most of the anticancer drugs, such as paclitaxel, doxorubicin and camptothecin, are insoluble in water (10). Drug-loaded nanoparticles that are infused in hydrogels have a number of advantages; they can enhance the drug penetration through the skin and modify the drug activation activity, which consequently will optimizes drug efficacy (21). In this study, conducted by Saeednia et al.they also discovered that the inclusion of carbon nanotubes loaded with methotrexate in chitosan-β-glycerophosphate hydrogel improved the swelling behavior of the formulation and prolonged drug release, enhancing death of MCF-7 breast cancer cells (25). Besides medication, hydrogel-nanoparticle hybrids have been discovered to be useful for application in tumor resection.