The impact of obstructive sleep apnea on homocysteine and carotid remodeling in metabolic syndrome

• Published in: Respiratory physiology & neurobiology Vol. 180; no. 2; pp. 298 - 304
• Main Authors: Monneret, D, Tamisier, R, Ducros, V, Garrel, C, Levy, P, Baguet, J.P, Faure, P, Pépin, J.L
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2012
• Subjects: Antioxidants - metabolism; Arousal - physiology; Atherosclerosis - complications; Atherosclerosis - metabolism; Blood Pressure - physiology; Carotid Arteries - diagnostic imaging; Carotid Arteries - pathology; Carotid Intima-Media Thickness; Chromatography, High Pressure Liquid; Endothelium, Vascular - physiology; Female; Homocysteine; Homocysteine - metabolism; Humans; Isoprostanes - urine; Lipids - blood; Male; Medical Education; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - pathology; Middle Aged; Obstructive sleep apnea; Oxidation-Reduction; Oxidative stress; Oxidative Stress - physiology; Plasma thiols; Polysomnography; Pulmonary/Respiratory; Sleep Apnea, Obstructive - etiology; Sleep Apnea, Obstructive - metabolism; Sleep Apnea, Obstructive - pathology; Sulfhydryl Compounds - blood; Tandem Mass Spectrometry; Urinary 15-F2t-isoprostane; obstructive sleep apnea; blood pressure; Oxidative stress; AHI; LC/MS/MS; Urinary 15-F 2t-isoprostane; body mass index; pulse wave velocity; BP; PWV; metabolic syndrome; IMT; intima-media thickness; MetS; liquid chromatography–tandem mass spectrometry; apnea–hypopnea index; Carotid intima-media thickness; OSA; Homocysteine; Plasma thiols; BMI; Metabolic syndrome; Obstructive sleep apnea; Urinary 15-F2t-isoprostane
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2011.12.009

Highlights ► Homocysteine (Hcy) level remains disputed in OSA. ► Assessment of Hcy, CIMT and oxidative stress in metabolic syndrome ± OSA patients. ► Hcy was increased in OSA + MetS group compared to MetS. ► Hcy was associated with AHI and CIMT and oxidative stress. ► Hcy was related to vascular remodeling in OSA.