Naloxone pro-drug rescues morphine induced respiratory depression in Sprague-Dawley rats

Highlights ► Newly synthesized naloxone pro-drug is examined in vivo in the rat. ► Morphine induced respiratory depression is studied using plethysmography. ► Naloxone pro-drug releases naloxone in response to morphine overdose. ► Naloxone pro-drug rescues respiratory depression from morphine overdo...

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Bibliographic Details
Published inRespiratory physiology & neurobiology Vol. 180; no. 1; pp. 52 - 60
Main Authors Wallisch, Michael, El Rody, Nehad M, Huang, Baohua, Koop, Dennis R, Baker, James R, Olsen, George D
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.01.2012
Subjects
Analgesics, Opioid - toxicity
Animals
Chromatography, High Pressure Liquid
Delivery vehicle
Male
Medical Education
Morphine
Morphine - toxicity
Naloxone
Naloxone - administration & dosage
Naloxone - pharmacokinetics
Narcotic Antagonists - administration & dosage
Narcotic Antagonists - pharmacokinetics
Plethysmography
Prodrugs - administration & dosage
Prodrugs - pharmacokinetics
Pulmonary/Respiratory
Rats
Rats, Sprague-Dawley
Respiratory depression
Respiratory Insufficiency - chemically induced
Respiratory Insufficiency - drug therapy
Delivery vehicle
Morphine
Naloxone
Respiratory depression
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Summary:Highlights ► Newly synthesized naloxone pro-drug is examined in vivo in the rat. ► Morphine induced respiratory depression is studied using plethysmography. ► Naloxone pro-drug releases naloxone in response to morphine overdose. ► Naloxone pro-drug rescues respiratory depression from morphine overdose.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2011.10.009