The role of optical coherence tomography and infrared oculography in assessing the visual pathway and CNS in multiple sclerosis

• Published in: Neurodegenerative disease management Vol. 8; no. 5; pp. 323 - 335
• Main Authors: Coric, Danko, Nij Bijvank, Jenny A, van Rijn, Laurentius J, Petzold, Axel, Balk, Lisanne J
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.10.2018
• Subjects: Alzheimer's disease; Biomarkers; Disability; Eye - diagnostic imaging; Eye movements; Humans; infrared oculography; Infrared Rays; Multiple sclerosis; Multiple Sclerosis - diagnostic imaging; Neurodegeneration; optical coherence tomography; Optics; Quality of life; Systematic review; Tomography; Tomography, Optical Coherence; Visual Pathways - diagnostic imaging; visual system; visual system; infrared oculography; optical coherence tomography; multiple sclerosis
• ISSN: 1758-2024; 1758-2032
• DOI: 10.2217/nmt-2018-0011

In this review, a current overview is provided of how optical coherence tomography and infrared oculography can aid in assessing the visual system and CNS in multiple sclerosis (MS). Both afferent and efferent visual disorders are common in MS and visual complaints can have a tremendous impact on daily functioning. Optical coherence tomography and infrared oculography can detect and quantify visual disorders with high accuracy, but could also serve as quantitative markers for inflammation, neurodegeneration and network changes including cognitive decline in MS patients. The assessment of the efferent and afferent visual pathways is relevant for monitoring and predicting the disease course, but is also potentially valuable as an outcome measure in therapeutic trials.