Therapeutic strategies against bacterial biofilms

The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy. The formation of bacterial biofilms is one of the main reasons of bacterial resistance. The complexity of chemical composition and physical structure makes the elimination of mature biofilms...

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Bibliographic Details
Published inFundamental research (Beijing) Vol. 1; no. 2; pp. 193 - 212
Main Authors Bi, Yufang, Xia, Guixue, Shi, Chao, Wan, Jianglin, Liu, Longqiang, Chen, Yuan, Wu, Yueming, Zhang, Wenjing, Zhou, Min, He, Hongyan, Liu, Runhui
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2021
KeAi Communications Co. Ltd
Subjects
Antimicrobial resistance
Biofilm
Drug delivery
Nanomaterials
Persister cell
Biofilm
Nanomaterials
Drug delivery
Antimicrobial resistance
Persister cell
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Summary:The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy. The formation of bacterial biofilms is one of the main reasons of bacterial resistance. The complexity of chemical composition and physical structure makes the elimination of mature biofilms a difficult problem. The highly antibiotic resistant property of biofilms urgently calls for potent antimicrobial agents and novel antibiofilm strategies. Researchers have made a lot of efforts in this field. Here we review the current strategies to eliminate mature biofilms and progress in related drug delivery nanosystems, with the aim of inspiring researchers to design new antibiofilm systems. [Display omitted]
ISSN:2667-3258
2667-3258
DOI:10.1016/j.fmre.2021.02.003