Sustainable cutaneous gene delivery

Durable gene delivery to human skin is necessary for lasting correction of human genetic skin disease. Current cutaneous gene-delivery strategies, however, have achieved only transient gene expression, often only within a small percentage of tissue cells. The recent inability to sustain phenotypic c...

Full description

Saved in:
Bibliographic Details
Published inNature biotechnology Vol. 15; no. 13; pp. 1388 - 1391
Main Authors Deng, Helen, Lin, Qun, Khavari, Paul A
Format Journal Article
LanguageEnglish
Published New York, NY Nature 01.12.1997
Subjects
Animals
Biological and medical sciences
Biotechnology
Cells, Cultured
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Viral - genetics
Gene therapy
Genetic Engineering
Genetic Therapy
Genetic Vectors
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Keratinocytes - cytology
Liver - cytology
Liver - drug effects
Mice
Mice, Transgenic
Phenotype
Promoter Regions, Genetic
Retroviridae - genetics
Skin - cytology
Skin - metabolism
Skin Diseases - genetics
Skin Diseases - therapy
Virus
Human
Delivery system
Skin disease
Retroviridae
Genetic character
Gene expression
Gene therapy
Vector
Genetic disease
Online AccessGet full text

Cover

More Information
Summary:Durable gene delivery to human skin is necessary for lasting correction of human genetic skin disease. Current cutaneous gene-delivery strategies, however, have achieved only transient gene expression, often only within a small percentage of tissue cells. The recent inability to sustain phenotypic correction of human genetic skin disease due to loss of therapeutic gene expression in regenerated epidermal tissue has highlighted this current limitation. In an effort to surmount this problem, we have generated gene delivery vectors that produce more durable gene delivery in human skin tissue in vivo.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt1297-1388