SIRT6 Inhibits Anoikis of Colorectal Cancer Cells by Down-Regulating NDRG1

Anoikis, a form of apoptosis resulting from the loss of cell–extracellular matrix interaction, is a significant barrier to cancer cell metastasis. However, the epigenetic regulation of this process remains to be explored. Here, we demonstrate that the histone deacetylase sirtuin 6 (SIRT6) plays a pi...

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Published inInternational journal of molecular sciences Vol. 25; no. 11; p. 5585
Main Authors Li, Fengying, Yu, Wentao, Zhou, Xiaoling, Hou, Jingyu, Gao, Yunyi, Zhang, Jun, Gao, Xiangwei
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2024
MDPI
Subjects
anoikis
Apoptosis
Cell adhesion & migration
China
Colorectal cancer
Cytokines
Development and progression
Epigenetic inheritance
epigenetic regulation
Epigenetics
Gene expression
Health aspects
Kinases
Medical prognosis
Metabolism
Metastasis
Mortality
NDRG1
Phosphorylation
Plasma
Proteins
Signal transduction
SIRT6
China
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Summary:Anoikis, a form of apoptosis resulting from the loss of cell–extracellular matrix interaction, is a significant barrier to cancer cell metastasis. However, the epigenetic regulation of this process remains to be explored. Here, we demonstrate that the histone deacetylase sirtuin 6 (SIRT6) plays a pivotal role in conferring anoikis resistance to colorectal cancer (CRC) cells. The protein level of SIRT6 is negatively correlated with anoikis in CRC cells. The overexpression of SIRT6 decreases while the knockdown of SIRT6 increases detachment-induced anoikis. Mechanistically, SIRT6 inhibits the transcription of N-myc downstream-regulated gene 1 (NDRG1), a negative regulator of the AKT signaling pathway. We observed the up-regulation of SIRT6 in advanced-stage CRC samples. Together, our findings unveil a novel epigenetic program regulating the anoikis of CRC cells.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25115585