Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc
We previously reported the structure of the placentally derived human cysteine-rich (h crp) cDNA and demonstrated that it encodes a highly conserved and widely distributed zinc finger-like protein. We now report that the expression of both the mouse and human crp genes is induced as a primary respon...
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Published in | The Journal of biological chemistry Vol. 267; no. 13; pp. 9176 - 9184 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Biochemistry and Molecular Biology
05.05.1992
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Subjects | |
Online Access | Get full text |
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Summary: | We previously reported the structure of the placentally derived human cysteine-rich (h crp) cDNA and demonstrated that it
encodes a highly conserved and widely distributed zinc finger-like protein. We now report that the expression of both the
mouse and human crp genes is induced as a primary response to serum in quiescent Balb/c 3T3 cells and in human fibroblasts.
The profile of this primary response is remarkably parallel to that of c-myc in the Balb/c 3T3 cell line. The structure of
the 23.2-kilobase h crp gene demonstrates that it is a member of a gene superfamily encoding proteins sharing a highly characteristic
52-amino acid "LIM/double-finger" motif. The evolutionarily conserved structure of cysteine-rich protein, its structural similarity
to a number of developmentally critical proteins, its distinctive tissue distribution, and its primary response to early events
in the cell cycle suggest that crp plays an important role in cell function. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0021-9258 1083-351X |
DOI: | 10.1016/S0021-9258(19)50405-7 |