A Mild Method for the Preparation of 1,3,4-Oxadiazoles: Triflic Anhydride Promoted Cyclization of Diacylhydrazines

Diacylhydrazines undergo cyclization upon treatment with triflic anhydride and pyridine to form the corresponding 1,3,4-oxadiazoles in yields ranging from 70--95%.

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Bibliographic Details
Published inSynthetic communications Vol. 30; no. 3; pp. 437 - 443
Main Authors Liras, Spiros, Allen, Martin P., Segelstein, Barb E.
Format Journal Article
LanguageEnglish
Published NEW YORK Taylor & Francis Group 01.02.2000
Marcel Dekker Inc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CHEMISTRY
SECONDARY
PSEUDOMONIC ACID
AMIDES
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Summary:Diacylhydrazines undergo cyclization upon treatment with triflic anhydride and pyridine to form the corresponding 1,3,4-oxadiazoles in yields ranging from 70--95%.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910008087340