The synthesis, surface analysis, and cellular response of titania and titanium oxynitride nanotube arrays prepared on TiAl6V4 for potential biomedical applications

Titania nanotubes are gaining prominence in the biomedical field as implant materials due to their mechanical durability, nano-rough properties, and positive influence on cellular response. This work aimed to synthesize titania and titanium oxynitride (Ti–O–N) nanotubular arrays on TiAl6V4 substrate...

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Published inJournal of materials research and technology Vol. 24; pp. 4074 - 4090
Main Authors Kravanja, Katja Andrina, Suhadolnik, Luka, Bele, Marjan, Maver, Uroš, Rožanc, Jan, Knez, Željko, Marevci, Maša Knez, Finšgar, Matjaž
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2023
Elsevier
Subjects
AFM
Anodization
Surface analysis
Tandem ToF-SIMS
Titania nanotubes
Ti–O–N nanotubes
XPS
Ti–O–N nanotubes
Tandem ToF-SIMS
AFM
XPS
Surface analysis
Anodization
Titania nanotubes
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Summary:Titania nanotubes are gaining prominence in the biomedical field as implant materials due to their mechanical durability, nano-rough properties, and positive influence on cellular response. This work aimed to synthesize titania and titanium oxynitride (Ti–O–N) nanotubular arrays on TiAl6V4 substrates using an anodic oxidation process followed by annealing in air or by additional nitridation in NH3 atmosphere. Different nanotubular layers of unique morphology and structure were fabricated and investigated using advanced surface analysis and biocompatibility tests. In-depth surface analysis was performed by field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM), 3D profilometry, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectroscopy (ToF-SIMS). Cell testing using adipose-derived mesenchymal stem cells and human fetal osteoblasts demonstrated good cell viability, high proliferative capacity, and a favorable overall effect on cell morphology for the Ti–O–N nanotubes. •Titania and titanium oxynitride nanotubes were fabricated on a TiAlV alloy•The obtained nanotubes were investigated by advanced surface analysis•3D spatial distribution of the nanotubes' constituents was determined•Biocompatibility was demonstrated towards mesenchymal stem cells and osteoblasts•The obtained nanotubes are promising for future biomedical applications
ISSN:2238-7854
DOI:10.1016/j.jmrt.2023.04.021