Effects of Hepatic Artery Chemoembolization Using Cisplatin–lipiodol Suspension with Gelatin Sponge Particles on Swine Liver

• Published in: Journal of vascular and interventional radiology Vol. 20; no. 10; pp. 1359 - 1364
• Main Authors: Sahara, Shinya, MD, Tanihata, Hirohiko, MD, Sato, Morio, MD, Kawai, Nobuyuki, MD, Takasaka, Isao, MD, Minamiguchi, Hiroyuki, MD, Nakai, Motoki, MD, Sonomura, Tetsuo, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2009
• Subjects: Animals; Antineoplastic Agents - toxicity; Chemoembolization, Therapeutic - adverse effects; Cisplatin - toxicity; Dose-Response Relationship, Drug; Hemostatics - toxicity; Iodized Oil - toxicity; Liver - drug effects; Liver - pathology; Radiology; Suspensions - toxicity; Swine; non–protein-bound platinum; plasma platinum; HCC; N-PBPt; PPt; hepatocellular carcinoma
• ISSN: 1051-0443; 1535-7732
• DOI: 10.1016/j.jvir.2009.06.028

Purpose To define the effects of hepatic artery chemoembolization with cisplatin–lipiodol suspension and gelatin sponge particles on swine liver tissue and estimate the concentration of cisplatin that would have a minimal negative effect on normal liver parenchyma. Materials and Methods Twelve pigs were divided into four groups: group A was the control group in which hepatic arteries were embolized with lipiodol and gelatin sponge particle ( n = 3); group B animals were embolized with 10 mg/mL cisplatin–lipiodol suspension plus gelatin sponge particle ( n = 3), group C with 20 mg/mL cisplatin–lipiodol suspension plus gelatin sponge particle ( n = 3), and group D with 30 mg/mL cisplatin–lipiodol suspension plus gelatin sponge particle ( n = 3). Pigs were euthanized 1 week after embolization, and the resected livers were cut into 10-mm-thick sections. The livers and necrotic foci were contoured in each section, and the necrosis volume ratio was calculated. Results The necrosis volume ratios of the livers in groups A, B, C, and D were 0.832% ± 0.334, 2.324% ± 1.126, 8.056% ± 3.276, and 11.82% ± 4.921, respectively. Significant differences ( P < .05) in necrosis volume ratio were found between groups A and C, groups A and D, groups B and C, and groups B and D; no significant difference was found between groups A and B. Conclusions Hepatic artery chemoembolization with higher doses of cisplatin causes greater damage to liver tissue; 10 mg/mL cisplatin–lipiodol suspension causes minimal damage, similar to that without cisplatin, and is related to minimal negative changes in a swine model.