Rapid method for detection of point mutations using mismatch binding protein (MutS) and an optical biosensor

This paper describes a new method for detecting DNA point mutations using a mismatch binding protein. The interactions of mismatches and mismatch binding proteins are detected by the optical biosensor technology based on surface plasmon resonance (SPR).

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Bibliographic Details
Published inGenetic analysis : biomolecular engineering Vol. 14; no. 2; pp. 47 - 50
Main Authors Gotoh, Masanori, Hasebe, Masahisa, Ohira, Tomoko, Hasegawa, Yukio, Shinohara, Yasuro, Sota, Hiroyuki, Nakao, Junji, Tosu, Mariko
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.1997
Subjects
Adenosine Triphosphatases
Adenosine Triphosphate - chemistry
Bacterial Proteins
Biosensing Techniques
Biosensor
DNA Mutational Analysis - methods
DNA, Neoplasm - analysis
DNA-Binding Proteins
Escherichia coli Proteins
Gene diagnosis
Humans
MutS
MutS DNA Mismatch-Binding Protein
Point Mutation
Surface plasmon resonance
Tumor Cells, Cultured
Surface plasmon resonance
MutS
Gene diagnosis
Biosensor
Point mutation
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Summary:This paper describes a new method for detecting DNA point mutations using a mismatch binding protein. The interactions of mismatches and mismatch binding proteins are detected by the optical biosensor technology based on surface plasmon resonance (SPR).
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SourceType-Scholarly Journals-1
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ISSN:1050-3862
DOI:10.1016/S1050-3862(97)00009-0