A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy

Diabetes mellitus is one of the most common chronic diseases across the world. Cardiovascular complication is the major morbidity and mortality among the diabetic patients. Diabetic cardiomyopathy, a new entity independent of coronary artery disease or hypertension, has been increasingly recognized...

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Bibliographic Details
Published inEndocrine Vol. 41; no. 3; pp. 398 - 409
Main Authors Zhang, Xinli, Chen, Chen
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.06.2012
Subjects
Animals
Diabetes
Diabetic Cardiomyopathies - diagnosis
Diabetic Cardiomyopathies - physiopathology
Diabetic Cardiomyopathies - therapy
Endocrinology
Heart - physiopathology
Humanities and Social Sciences
Humans
Internal Medicine
Medicine
Medicine & Public Health
multidisciplinary
Review
Science
Oxidative stress
Treatment
Fatty acid
Impaired calcium handling
Diabetic cardiomyopathy
Diagnosis
Ion channel
Cardiac dysfunction
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Summary:Diabetes mellitus is one of the most common chronic diseases across the world. Cardiovascular complication is the major morbidity and mortality among the diabetic patients. Diabetic cardiomyopathy, a new entity independent of coronary artery disease or hypertension, has been increasingly recognized by clinicians and epidemiologists. Cardiac dysfunction is the major characteristic of diabetic cardiomyopathy. For a better understanding of diabetic cardiomyopathy and necessary treatment strategy, several pathological mechanisms such as impaired calcium handling and increased oxidative stress, have been proposed through clinical and experimental observations. In this review, we will discuss the development of cardiac dysfunction, the mechanisms underlying diabetic cardiomyopathy, diagnostic methods, and treatment options.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-012-9623-1