Proton Pump Inhibitors Directly Block hERG-Potassium Channel and Independently Increase the Risk of QTc Prolongation in a Large Cohort of US Veterans

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Bibliographic Details
Published inCirculation. Arrhythmia and electrophysiology Vol. 14; no. 7; p. e010042
Main Authors Lazzerini, Pietro Enea, Cartocci, Alessandra, Qu, Yongxia Sarah, Saponara, Simona, Furini, Simone, Fusi, Fabio, Fabris, Frank, Gamberucci, Alessandra, El-Sherif, Nabil, Cevenini, Gabriele, Pettini, Francesco, Laghi-Pasini, Franco, Acampa, Maurizio, Bertolozzi, Iacopo, Capecchi, Pier Leopoldo, Lazaro, Deana, Boutjdir, Mohamed
Format Journal Article
LanguageEnglish
Published United States 01.07.2021
Subjects
Cells, Cultured
Electrocardiography
ERG1 Potassium Channel - metabolism
Female
Humans
Incidence
Long QT Syndrome - drug therapy
Long QT Syndrome - physiopathology
Male
Middle Aged
Proton Pump Inhibitors - therapeutic use
Treatment Outcome
United States - epidemiology
Veterans
United States
proton pump inhibitors
torsade de pointes
veterans
odds ratio
ion channels
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Summary:[Figure: see text].
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ISSN:1941-3149
1941-3084
DOI:10.1161/circep.121.010042