Effects of perilla extract on productive performance, serum values and hepatic expression of lipid-related genes in Shaoxing ducks

• Published in: British poultry science Vol. 52; no. 3; pp. 381 - 387
• Main Authors: Liu, W.M, Zhang, J, Lu, L.Z, Shi, F.X, Niu, D, Wang, D.L, Yu, B, Tao, Z.R, Shen, J.D, Wang, D.Q, Tian, Y
• Format: Journal Article
• Language: English
• Published: England Longman 01.06.2011; Taylor & Francis Group
• Subjects: acetyl-CoA carboxylase; Acyl-CoA Oxidase - metabolism; Animal Feed; Animals; apolipoprotein B; blood lipids; Cholesterol - blood; Cholesterol, HDL - blood; Diet - veterinary; ducks; Ducks - genetics; Ducks - metabolism; fatty acid-binding proteins; Fatty Acid-Binding Proteins - genetics; Fatty Acid-Binding Proteins - metabolism; fatty liver; fatty-acid synthase; Female; gene expression; Gene Expression Regulation - drug effects; genes; high density lipoprotein cholesterol; Lipid Metabolism; Lipoproteins - blood; Liver - drug effects; Liver - physiology; messenger RNA; oviposition; Perilla - chemistry; Plant Extracts - pharmacology; Polymerase Chain Reaction; polyunsaturated fatty acids; PPAR alpha - genetics; PPAR alpha - metabolism; Reproduction - drug effects; RNA, Messenger - analysis; RNA, Messenger - genetics; stearoyl-CoA desaturase; Triglycerides - blood; very low density lipoprotein
• ISSN: 0007-1668; 1466-1799; 1466-1799
• DOI: 10.1080/00071668.2011.577053

1. The aim of this study was to identify the effect of perilla extract, a source of polyunsaturated fatty acids, on lipid metabolism and expression of lipid-related genes in livers of Shaoxing ducks. 2. Two hundred and forty 28-week-old laying ducks received a commercial diet with perilla extract added at 0 (control) or 200 mg/kg of feed. 3. Ducks fed on a diet with perilla extract had increased laying rates compared with control ducks. 4. Serum concentrations of triglycerides were reduced by perilla extract, while high-density lipoprotein cholesterol and total serum cholesterol increased. 5. The expression of genes involved in hepatic lipogenesis, sterol regulatory element-binding protein-1, acetyl CoA carboxylase, stearoyl CoA desaturase, fatty acid synthase, apolipoprotein B, and apolipoprotein very low density lipoprotein, were decreased in the perilla group. 6. The mRNA expression of peroxisome proliferators-activated receptor alpha and acyl-coenzyme A oxidase was enhanced following treatment with perilla extract, and a similar tendency was observed in the expression of liver fatty acid-binding protein. 7. The results show that a diet with 200 mg/kg perilla extract regulated fat metabolism of Shaoxing ducks by improving egg laying, altering serum lipid profiles, stimulating lipid catabolic gene expression and inibiting lipogenic gene expression in the liver.