Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors

A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 28; pp. 7968 - 7970
Main Authors Jourden, Jody L. Major, Daniel, Kevin B., Cohen, Seth M.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.07.2011
Subjects
chemical communication
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Drug Design
hydrogen peroxide
Hydrogen Peroxide - chemistry
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases - chemistry
Matrix Metalloproteinases - metabolism
metalloproteinases
metalloproteins
Metals - metabolism
Physical Sciences
Protease Inhibitors - chemistry
Protease Inhibitors - metabolism
Protease Inhibitors - pharmacology
salicylates
Science & Technology
SULFONAMIDES
ACID
CLINICAL-APPLICATIONS
PRODRUGS
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Summary:A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.
Bibliography:ObjectType-Article-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c1cc12526e