Preoperative fibrinogen to prealbumin ratio as a novel predictor for clinical outcome of hepatocellular carcinoma

• Published in: Future oncology (London, England) Vol. 15; no. 1; pp. 13 - 22
• Main Authors: Zhang, Lei, Chen, Qing-Gen, Li, Shu-Qi, Zhang, Jing, Min, Qing-Hua, Gao, Qiu-Fang, Sun, Fan, Jiang, Yu-Huan, Wang, Xiao-Zhong, Ying, Hou-Qun
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.01.2019
• Subjects: Adult; Angiogenesis; Biomarkers; Cancer therapies; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - surgery; Chemotherapy; Clinical outcomes; Cytokines; Female; Fibrinogen - analysis; FPR; HCC; Hepatectomy; Humans; Inflammation; Kaplan-Meier Estimate; Liver cancer; Liver Neoplasms - blood; Liver Neoplasms - mortality; Liver Neoplasms - surgery; Lung cancer; Lymphocyte Count; Lymphocytes; Male; Medical prognosis; Medical records; Metastasis; Middle Aged; Monocytes - cytology; Neutrophils; Neutrophils - cytology; Nutrition; Patients; Prealbumin - analysis; Preoperative Care; Prognosis; Software; Treatment Outcome; United States > US; Japan; inflammation; FPR; HCC
• ISSN: 1479-6694; 1744-8301
• DOI: 10.2217/fon-2018-0376

To investigate prognostic value of preoperative inflammatory biomarkers in hepatocellular carcinoma (HCC). Preoperative circulating fibrinogen, prealbumin, fibrinogen to prealbumin ratio (FPR), neutrophil to lymphocyte ratio, derived neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, platelet to lymphocyte ratio were detected and calculated in 230 HCC patients. X-tile software, Kaplan-Meier curve, Cox regression, time-dependent receiver-operating characteristic were used to explored prognostic roles of them in HCC. Multivariate Cox regression showed that high FPR was significantly associated with decreased recurrence-free survival (p = 0.034) and overall survival (p < 0.001) within HCC patients. FPR generated the largest area under curve of time-dependent receiver-operating characteristic comparing to the other biomarkers. Overall survival of HCC patients receiving chemotherapy was superior to the cases without receiving chemotherapy only in high FPR subgroup (p = 0.028). Preoperative FPR was superior to other biomarkers to independently predict survival of HCC patients, and it could identify the patients who could benefit from adjuvant chemotherapy.