On the mechanism of variation of pancreatic amylase levels in mouse strains

• Published in: The Journal of biological chemistry Vol. 256; no. 12; pp. 6502 - 6506
• Main Authors: Owerbach, D, Nielsen, J T, Rutter, W J
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 25.06.1981
• Subjects: Amylases - genetics; Amylases - metabolism; Animals; Base Sequence; DNA; DNA Restriction Enzymes; Isoenzymes - metabolism; Mice; Mice, Inbred C3H - genetics; Mice, Inbred C57BL - genetics; Nucleic Acid Hybridization; Pancreas - enzymology; Pancreatic Elastase - metabolism; Rats; RNA, Messenger - metabolism

The relative levels of pancreatic amylase mRNA closely parallel the 3-fold variation of pancreatic amylase protein levels observed in several mouse strains studied. In contrast pancreatic elastase mRNA levels were similar in these strains. Each of the strains contained the same number of amylase-lik...