On the mechanism of variation of pancreatic amylase levels in mouse strains

The relative levels of pancreatic amylase mRNA closely parallel the 3-fold variation of pancreatic amylase protein levels observed in several mouse strains studied. In contrast pancreatic elastase mRNA levels were similar in these strains. Each of the strains contained the same number of amylase-lik...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 256; no. 12; pp. 6502 - 6506
Main Authors Owerbach, D, Nielsen, J T, Rutter, W J
Format Journal Article
LanguageEnglish
Published United States American Society for Biochemistry and Molecular Biology 25.06.1981
Subjects
Amylases - genetics
Amylases - metabolism
Animals
Base Sequence
DNA
DNA Restriction Enzymes
Isoenzymes - metabolism
Mice
Mice, Inbred C3H - genetics
Mice, Inbred C57BL - genetics
Nucleic Acid Hybridization
Pancreas - enzymology
Pancreatic Elastase - metabolism
Rats
RNA, Messenger - metabolism
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Summary:The relative levels of pancreatic amylase mRNA closely parallel the 3-fold variation of pancreatic amylase protein levels observed in several mouse strains studied. In contrast pancreatic elastase mRNA levels were similar in these strains. Each of the strains contained the same number of amylase-like genes (about 8). The selective variation in the pancreatic amylase gene expression could be due either to differences in the numbers of active amylase genes or to different rates of synthesis and/or degradation of the amylase mRNA from a constant number of genes.
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ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(19)69194-5