Stereotactic Radiosurgery in Combination With Chemotherapy as Primary Treatment for Head and Neck Cancer

• Published in: Journal of oral and maxillofacial surgery Vol. 70; no. 2; pp. 461 - 472
• Main Authors: Kawaguchi, Koji, DDS, PhD, Sato, Kengo, MD, Yamada, Hiroyuki, DDS, PhD, Horie, Akihisa, DDS, Nomura, Takayoshi, DDS, PhD, Iketani, Susumu, DDS, PhD, Kanai, Ikuyo, DDS, PhD, Suzuki, Satoshi, DDS, PhD, Nakatani, Yasunori, DDS, Hamada, Yoshiki, DDS, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2012
• Subjects: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - surgery; Chemotherapy, Adjuvant; Dentistry; Disease Progression; Drug Combinations; Feasibility Studies; Female; Fluorouracil - administration & dosage; Follow-Up Studies; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - surgery; Humans; Lymphatic Metastasis - diagnosis; Magnetic Resonance Imaging - methods; Male; Middle Aged; Multimodal Imaging - methods; Neoplasm Recurrence, Local - prevention & control; Neoplasm Staging; Oxonic Acid - administration & dosage; Patient Care Planning; Positron-Emission Tomography; Radiosurgery; Remission Induction; Retrospective Studies; Surgery; Survival Rate; Tegafur - administration & dosage; Tomography, X-Ray Computed - methods; Treatment Outcome
• ISSN: 0278-2391; 1531-5053
• DOI: 10.1016/j.joms.2011.02.063

Purpose The purpose of this study was to investigate the effect of stereotactic radiosurgery on local control and organ preservation in cases of primary head and neck cancer. Patients and Methods In this retrospective study, 14 patients with a mean age of 73 years were treated between March 2006 and September 2007 with stereotactic radiosurgery for the management of primary head and neck cancer. The patients had biopsy confirmation of disease before treatment and all patients were confirmed with squamous cell carcinoma. The staging consisted of T2 (5 cases), T3 (3 cases), T4 (6 cases), N0 (13 cases), and N1 (1 case). Marginal doses were 3,500 to 4,200 cGy in 3 or 5 fractions. The outcome was assessed according to Response Evaluation Criteria in Solid Tumors criteria based on magnetic resonance imaging and positron emission tomography/computed tomography. Results Significant tumor reduction was noted at the third month of follow-up with 5 complete responses and 9 partial responses. At a mean follow-up of 36 months (range, 14-40 mo) the local control and overall survival rates were 71.4% (10/14) and 78.6% (11/14), respectively. Conclusions These results show the feasibility of using stereotactic radiosurgery for primary head and neck cancer and its potential benefit in local control and organ preservation.