Selenoprotein P in Plasma in Relation to Cancer Morbidity in Middle-Aged Swedish Men

• Published in: Nutrition and cancer Vol. 36; no. 1; pp. 19 - 26
• Main Authors: Persson-Moschos, Marie E. K., Stavenow, Lars, Åkesson, Bjorn, Lindgärde, Folke
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Lawrence Erlbaum Associates, Inc 01.01.2000; Taylor& Francis
• Subjects: albumins; alpha 1-Antitrypsin; alpha 1-Antitrypsin - analysis; analysis; Biological and medical sciences; blood; Blood Glucose; Blood Glucose - analysis; blood lipids; blood plasma; blood pressure; Body Mass Index; body weight; carbon monoxide; Carcinogenesis, carcinogens and anticarcinogens; Case-Control Studies; cholesterol; Cohort Studies; Digestive System Neoplasms; Digestive System Neoplasms - blood; digestive tract; epidemiology; Foods and miscellaneous; gamma-glutamyltransferase; gamma-Glutamyltransferase - blood; hemoglobin; Humans; immunoglobulin G; Male; Medical sciences; men; Middle Aged; middle-aged adults; Morbidity; neoplasms; Neoplasms - blood; Neoplasms - epidemiology; nutritional status; Odds Ratio; Proteins; Proteins - analysis; respiratory system; Respiratory Tract Neoplasms; Respiratory Tract Neoplasms - blood; Risk Factors; Selenoprotein P; Selenoproteins; Serum Albumin; Serum Albumin - analysis; Smoking; smoking (habit); Smoking - blood; Sweden; Tumors; urinary tract; Urologic Neoplasms; Urologic Neoplasms - blood; Sweden; Europe; Human; Correlation; Selenoprotein; Risk factor; Case control study; Malignant tumor; Epidemiology; Morbidity; Quantitative analysis
• ISSN: 0163-5581; 1532-7914
• DOI: 10.1207/S15327914NC3601_4

The premorbid level of selenoprotein P in plasma from subjects with cancer at different sites was compared with that from control subjects in a nested case-control study. A health screening of 12,500 middle-aged men was performed during 1974-1982 in Malmö, Sweden,, and from the 400 cancer cases that were identified during follow-up until the end of 1988, 302 plasma samples were available for analysis of selenoprotein P. Two living controls per case of the same screening day and age were chosen. Selenoprotein P levels in subgroups of major cancer sites were lower in cases than in controls for the respiratory tract (1.20 and 1.30 arbitrary units, respectively; p < 0.05) cancer group. The odds ratio for overall cancer risk in the lowest quintile of selenoprotein P level compared with that in the highest was 5.2 [p (for trend) = 0.01]. In subgroups of major cancer sites, the odds ratios for cancer risk in the lowest tertile compared with the highest were 6.0 [p (for trend) = 0.004] in the respiratory tract and 3.4 [p (for trend) = 0.002] in the digestive tract. In cases + controls, selenoprotein P was lower in smokers than in nonsmokers (p < 0.05). Selenoprotein P was significantly correlated to plasma albumin, fasting blood glucose, and body mass index and inversely correlated to plasma α1-antitrypsin and γ-glutamyl transferase. The results suggest that a low plasma selenoprotein P level is associated with higher future risk of respiratory and digestive tract cancer in middle-aged men.