Merlin's wizardry guides cohesive migration

Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin-Rich1 complex and t...

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Bibliographic Details
Published inNature cell biology Vol. 17; no. 3; pp. 212 - 213
Main Authors Zoch, Ansgar, Morrison, Helen
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.03.2015
Subjects
Animals
Cell migration
Cellular control mechanisms
Genetic aspects
Humans
Keratinocytes - metabolism
Mechanotransduction, Cellular - genetics
Neurofibromin 2 - metabolism
Properties
Pseudopodia - metabolism
rac1 GTP-Binding Protein - metabolism
Tumor suppressor genes
United Kingdom
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Summary:Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin-Rich1 complex and the Rac1 small GTPase.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Commentary-1
ISSN:1465-7392
1476-4679
DOI:10.1038/ncb3126