Sensitivity and specificity of stroboscopy in preoperative differentiation of dysplasia from early invasive glottic carcinoma

• Published in: European archives of oto-rhino-laryngology Vol. 272; no. 5; pp. 1189 - 1193
• Main Authors: El-Demerdash, A., Fawaz, S. A., Sabri, S. M., Sweed, Ahmed, Rabie, H.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2015
• Subjects: Adult; Carcinoma - pathology; Carcinoma - surgery; Diagnosis, Differential; Female; Glottis - pathology; Glottis - surgery; Head and Neck Surgery; Humans; Hyperplasia - diagnosis; Laryngeal Neoplasms - pathology; Laryngeal Neoplasms - surgery; Laryngology; Leukoplakia - diagnosis; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness; Neurosurgery; Otorhinolaryngology; Patient Selection; Precancerous Conditions; Predictive Value of Tests; Preoperative Care; Sensitivity and Specificity; Stroboscopy - methods; Dysplasia; Videostroboscopy; Leukoplakia; Invasive carcinoma
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-015-3530-z

Leukoplakia is a descriptive clinical term designating a white patch or plaque of the mucosa and must be complemented by histology, which can range from simple totally benign keratosis with or without atypia up to invasive carcinoma. The aim of this study is to evaluate the accuracy of videostroboscopy in preoperative differentiation of early invasive glottic carcinoma from intraepithelial atypia and dysplasia. 46 patients with a total of 60 leukoplakia lesions on the vocal folds were included in the study. Videostroboscopy was used to divide them into two groups based on preservation of the mucosal wave and this was correlated with the final pathology after treatment. The sensitivity and specificity of videostroboscopy in predicting invasive nature of the lesions based on absence or reduction of the mucosal wave were 96.8 and 92.8 %, respectively, with an overall accuracy of 95 %. We suggest that routine application of videostroboscopy can be an important, simple, non-invasive tool, to achieve, in a single procedure, proper and accurate evaluation of glottic leukoplakia.