Nanomedicines for cancer therapy: current status, challenges and future prospects

The emergence of nanomedicine as an innovative and promising alternative technology shows many advantages over conventional cancer therapies and provides new opportunities for early detection, improved treatment, and diagnosis of cancer. Despite the cancer nanomedicines' capability of deliverin...

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Bibliographic Details
Published inTherapeutic delivery Vol. 10; no. 2; pp. 113 - 132
Main Authors Bor, Gizem, Mat Azmi, Intan Diana, Yaghmur, Anan
Format Journal Article
LanguageEnglish
Published England Future Science Ltd 01.02.2019
Newlands Press
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
biological barriers
Blood circulation
Cancer
cancer nanomedicines
Cancer therapies
chemotherapeutic agents
Chemotherapy
Clinical trials
Drug Carriers - chemistry
Drug Carriers - metabolism
drug delivery
Drugs
FDA approval
Federal regulation
Government Regulation
Half-Life
Humans
Nanomedicine
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - metabolism
Nanotechnology
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - pathology
Protein interaction
Toxicity
Tumor Microenvironment
Tumorigenesis
Tumors
nanoparticles
biological barriers
drug delivery
tumor microenvironment
chemotherapeutic agents
cancer nanomedicines
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Summary:The emergence of nanomedicine as an innovative and promising alternative technology shows many advantages over conventional cancer therapies and provides new opportunities for early detection, improved treatment, and diagnosis of cancer. Despite the cancer nanomedicines' capability of delivering chemotherapeutic agents while providing lower systemic toxicity, it is paramount to consider the cancer complexity and dynamics for bridging the translational bench-to-bedside gap. It is important to conduct appropriate investigations for exploiting the tumor microenvironment, and achieving a more comprehensive understanding of the fundamental biological processes in cancer and their roles in modulating nanoparticle-protein interactions, blood circulation, and tumor penetration. This review provides an overview of the current cancer nanomedicines, the major challenges, and the future opportunities in this research area.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2018-0062