Case report: lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma
We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to p...
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| Published in | Future oncology (London, England) Vol. 15; no. 24s; pp. 13 - 19 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Future Medicine Ltd
01.08.2019
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| Subjects | |
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| Abstract | We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to pulmonary thromboembolism. The patient was therefore treated with lenvatinib with a neoadjuvant intent until hemodynamic stability was obtained. Thyroidectomy and radioiodine therapy were then performed and the postdose scan revealed an area of modest uptake in the anterior part of the neck. The patient is now in a good clinical status and she continues her follow-up program without any adjuvant therapy. |
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| AbstractList | We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to pulmonary thromboembolism. The patient was therefore treated with lenvatinib with a neoadjuvant intent until hemodynamic stability was obtained. Thyroidectomy and radioiodine therapy were then performed and the postdose scan revealed an area of modest uptake in the anterior part of the neck. The patient is now in a good clinical status and she continues her follow-up program without any adjuvant therapy. |
| Author | Mora, Marco Varaldo, Elisabetta Morbelli, Silvia Conte, Lucia Trambaiolo Antonelli, Chiara Minuto, Michele Gay, Stefano Teliti, Marsida Giusti, Massimo Ansaldo, Gianluca Zupo, Simonetta Comina, Martina Spina, Bruno Massa, Barbara Monti, Eleonora |
| AuthorAffiliation | 7Cyto-Histopathological Unit and Pathology Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy 8Nuclear Medicine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy 5Endocrine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy 3Pathology Unit, Policlinico San Martino, Genoa, 16132, Italy 6Endocrine Surgery Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy 2Pathology, Department of Integrated Surgical & Diagnostic Sciences, University of Genoa, Genoa, 16132, Italy 4Endocrine Surgery Unit, Policlinico San Martino, Genoa, 16132, Italy 1Endocrinology Unit, Policlinico San Martino, Genoa, 16132, Italy |
| AuthorAffiliation_xml | – name: 2Pathology, Department of Integrated Surgical & Diagnostic Sciences, University of Genoa, Genoa, 16132, Italy – name: 8Nuclear Medicine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – name: 4Endocrine Surgery Unit, Policlinico San Martino, Genoa, 16132, Italy – name: 5Endocrine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – name: 7Cyto-Histopathological Unit and Pathology Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – name: 1Endocrinology Unit, Policlinico San Martino, Genoa, 16132, Italy – name: 6Endocrine Surgery Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – name: 3Pathology Unit, Policlinico San Martino, Genoa, 16132, Italy |
| Author_xml | – sequence: 1 givenname: Stefano surname: Gay fullname: Gay, Stefano organization: Endocrinology Unit, Policlinico San Martino, Genoa, 16132, Italy – sequence: 2 givenname: Eleonora surname: Monti fullname: Monti, Eleonora organization: Endocrinology Unit, Policlinico San Martino, Genoa, 16132, Italy – sequence: 3 givenname: Chiara surname: Trambaiolo Antonelli fullname: Trambaiolo Antonelli, Chiara organization: Pathology, Department of Integrated Surgical & Diagnostic Sciences, University of Genoa, Genoa, 16132, Italy – sequence: 4 givenname: Marco surname: Mora fullname: Mora, Marco organization: Pathology Unit, Policlinico San Martino, Genoa, 16132, Italy – sequence: 5 givenname: Bruno surname: Spina fullname: Spina, Bruno organization: Pathology Unit, Policlinico San Martino, Genoa, 16132, Italy – sequence: 6 givenname: Gianluca surname: Ansaldo fullname: Ansaldo, Gianluca organization: Endocrine Surgery Unit, Policlinico San Martino, Genoa, 16132, Italy – sequence: 7 givenname: Marsida surname: Teliti fullname: Teliti, Marsida organization: Endocrine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 8 givenname: Martina surname: Comina fullname: Comina, Martina organization: Endocrine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 9 givenname: Lucia surname: Conte fullname: Conte, Lucia organization: Endocrine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 10 givenname: Michele surname: Minuto fullname: Minuto, Michele organization: Endocrine Surgery Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 11 givenname: Elisabetta surname: Varaldo fullname: Varaldo, Elisabetta organization: Endocrine Surgery Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 12 givenname: Simonetta surname: Zupo fullname: Zupo, Simonetta organization: Cyto-Histopathological Unit and Pathology Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 13 givenname: Barbara surname: Massa fullname: Massa, Barbara organization: Cyto-Histopathological Unit and Pathology Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 14 givenname: Silvia surname: Morbelli fullname: Morbelli, Silvia organization: Nuclear Medicine Unit, Thyroid GIP at the Policlinico Hospital San Martino, Genoa, 16132, Italy – sequence: 15 givenname: Massimo surname: Giusti fullname: Giusti, Massimo organization: Endocrinology Unit, Policlinico San Martino, Genoa, 16132, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31385546$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1089/thy.2016.0627 10.1038/modpathol.2010.117 10.1089/thy.2015.0316 10.1515/raon-2015-0001 10.1507/endocrj.EJ17-0104 10.1089/thy.2012.0403 10.1016/j.ijscr.2017.10.010 10.1089/thy.2012.0598 10.1089/thy.2016.0064 10.1007/s40266-015-0256-y 10.1002/hed.24357 10.1007/s00423-013-1142-x 10.1136/jclinpath-2013-201626 10.1089/thy.2012.0192 10.1089/thy.2018.0214 10.1002/hed.23152 10.1016/j.ejso.2017.05.002 10.1016/j.beem.2017.08.001 10.1056/NEJMoa1406470 10.1186/s12957-017-1096-5 10.1089/thy.2015.0020 10.1002/jso.24611 10.1016/j.ecl.2007.12.001 10.1272/jnms.2018_85-3 10.1002/hed.23619 10.1016/j.ijscr.2017.06.011 |
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| SubjectTerms | Aged, 80 and over Biopsy Bronchoscopy Cancer therapies Carcinoma, Papillary - diagnostic imaging Carcinoma, Papillary - drug therapy Carcinoma, Papillary - pathology Carcinoma, Papillary - surgery case report Case reports Dyspnea Female Humans Hypotheses Iodine Radioisotopes - administration & dosage lenvatinib Medical prognosis neoadjuvant Neoadjuvant Therapy Phenylurea Compounds - administration & dosage Quinolines - administration & dosage Radiation therapy Surgery Thromboembolism Thrombosis Thyroid cancer thyroid carcinoma Thyroid Neoplasms - diagnostic imaging Thyroid Neoplasms - drug therapy Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy Tumors Ultrasonic imaging |
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| Title | Case report: lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma |
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