Case report: lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma

We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to p...

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Published inFuture oncology (London, England) Vol. 15; no. 24s; pp. 13 - 19
Main Authors Gay, Stefano, Monti, Eleonora, Trambaiolo Antonelli, Chiara, Mora, Marco, Spina, Bruno, Ansaldo, Gianluca, Teliti, Marsida, Comina, Martina, Conte, Lucia, Minuto, Michele, Varaldo, Elisabetta, Zupo, Simonetta, Massa, Barbara, Morbelli, Silvia, Giusti, Massimo
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.08.2019
Subjects
Aged, 80 and over
Biopsy
Bronchoscopy
Cancer therapies
Carcinoma, Papillary - diagnostic imaging
Carcinoma, Papillary - drug therapy
Carcinoma, Papillary - pathology
Carcinoma, Papillary - surgery
case report
Case reports
Dyspnea
Female
Humans
Hypotheses
Iodine Radioisotopes - administration & dosage
lenvatinib
Medical prognosis
neoadjuvant
Neoadjuvant Therapy
Phenylurea Compounds - administration & dosage
Quinolines - administration & dosage
Radiation therapy
Surgery
Thromboembolism
Thrombosis
Thyroid cancer
thyroid carcinoma
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Tumors
Ultrasonic imaging
case report
neoadjuvant
thyroid carcinoma
lenvatinib
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Summary:We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to pulmonary thromboembolism. The patient was therefore treated with lenvatinib with a neoadjuvant intent until hemodynamic stability was obtained. Thyroidectomy and radioiodine therapy were then performed and the postdose scan revealed an area of modest uptake in the anterior part of the neck. The patient is now in a good clinical status and she continues her follow-up program without any adjuvant therapy.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2019-0099