Is Gilbert Syndrome a new risk factor for breast cancer?

Abstract Patients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens a...

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Bibliographic Details
Published inMedical hypotheses Vol. 77; no. 2; pp. 162 - 164
Main Authors Astolfi, Rafael Haddad, Bugano, Diogo Diniz Gomes, Francisco, Alice Aparecida Rodrigues Ferreira, Souza, Marcelo Moreira Tavares de, Ono-Nita, Suzane Kioko, Baracat, Edmund Chada
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.08.2011
Subjects
Breast Neoplasms - etiology
Breast Neoplasms - metabolism
Estrogens - metabolism
Female
Gilbert Disease - complications
Gilbert Disease - genetics
Gilbert Disease - metabolism
Glucuronosyltransferase - genetics
Glucuronosyltransferase - metabolism
Humans
Internal Medicine
Models, Biological
Polymorphism, Genetic - genetics
Risk Factors
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Summary:Abstract Patients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2011.03.047