Effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊) on Treatment of Functional Dyspepsia: A Meta-Analysis of Randomized Controlled Trials
Objective To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊, ZKC) for functional dyspepsia (FD) through meta-analysis. Methods Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized...
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Published in | Chinese journal of integrative medicine Vol. 25; no. 8; pp. 625 - 630 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.08.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Objective
To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊, ZKC) for functional dyspepsia (FD) through meta-analysis.
Methods
Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April, 2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale. RevMan 5.3 and GRADEprofiler 3.6 were used for statistical analysis and evidence quality assessment.
Results
Twenty-three trials with 2,496 patients were included and most of them were of poor methodological quality. ZKC alone or ZKC combined with routine Western medicine (WM) showed a better clinical effect rate compared with the control group of WM [odds ratio (OR)=3.32, 95% confidence interval (2.66, 4.15),
P
<0.00001]. No serious adverse reactions were reported.
Conclusions
ZKC alone or ZKC combined with routine WM could significantly improve the clinical effective rate in the treatment of FD. The quality of the evidence is low, so it is necessary to design multicenter, strictly randomized and double-blind controlled trials with large samples to validate the conclusions. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1672-0415 1993-0402 |
DOI: | 10.1007/s11655-018-2846-0 |