Responsiveness of Equine Basilar Artery to Transmural Nerve Stimulation Differs from That of Porcine and Bovine Basilar Arteries in Vitro

Transmural nerve stimulation (TNS) induced relaxations in porcine and bovine basilar arteries which were abolished by tetrodotoxin (TTX) and by L-nitro-arginine (LNAG). However, TNS induced contractions in equine basilar artery which were abolished by TTX and by guanethidine, but not by LNAG. These...

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Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 57; no. 2; pp. 365 - 366
Main Authors MIYAMOTO, Atsushi, KANDA, Junko, NISHIO, Akira
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.04.1995
Japan Science and Technology Agency
Subjects
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Basilar Artery - drug effects
Basilar Artery - innervation
Basilar Artery - physiology
Cattle - physiology
Dinoprost - pharmacology
Electric Stimulation
Endothelium, Vascular - physiology
equine basilar artery
Guanethidine - pharmacology
Horses - physiology
In Vitro Techniques
Isometric Contraction - drug effects
Muscle Relaxation - drug effects
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - innervation
Muscle, Smooth, Vascular - physiology
Nitroarginine
norepinephrine
Potassium Chloride - pharmacology
Species Specificity
Swine - physiology
Tetrodotoxin - pharmacology
transmural nerve stimulation
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Summary:Transmural nerve stimulation (TNS) induced relaxations in porcine and bovine basilar arteries which were abolished by tetrodotoxin (TTX) and by L-nitro-arginine (LNAG). However, TNS induced contractions in equine basilar artery which were abolished by TTX and by guanethidine, but not by LNAG. These results suggest that the TNS-induced contractions of equine basilar arteries may be mediated by norepinephrine release.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.57.365