Biological activities of imidazo[2,1-b][1,3,4]thiadiazole derivatives: A review

Imidazo[2,1-b][1,3,4]thiadiazole heterocycle was discovered during the 1950s. Since then, many newer derivatives are being developed and evaluated for their biological profiles. The derivatives of imidazo[2,1-b][1,3,4]thiadiazoles are widely explored for their biological potential viz. antimicrobial...

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Published inJournal of Saudi Chemical Society Vol. 20; no. S1; pp. S463 - S475
Main Authors Bhongade, Bhoomendra A., Talath, Sirajunisa, Gadad, Ravikiran A., Gadad, Andanappa K.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2016
Elsevier
Subjects
Biological activities
Imidazo [2,1-b][1,3,4]thiadiazole
Review
Imidazo [2,1-b][1,3,4]thiadiazole
Biological activities
Review
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Summary:Imidazo[2,1-b][1,3,4]thiadiazole heterocycle was discovered during the 1950s. Since then, many newer derivatives are being developed and evaluated for their biological profiles. The derivatives of imidazo[2,1-b][1,3,4]thiadiazoles are widely explored for their biological potential viz. antimicrobial, antifungal, anticancer, anticonvulsant, analgesic, antiinflammatory, anesthetic, and diuretic. They are also reported as potential enzyme inhibitors of cyclooxygenase, Jun kinase, carbonic anhydrase demonstrating their possible significance in target oriented drug design and discovery. The present review highlights the last six decades of research on biological activities of the imidazo[2,1-b][1,3,4]thiadiazoles.
ISSN:1319-6103
DOI:10.1016/j.jscs.2013.01.010