Relationship between obesity and serum lipoproteins in children with different apolipoprotein E phenotypes: the Bogalusa Heart Study

• Published in: Metabolism, clinical and experimental Vol. 43; no. 4; pp. 470 - 475
• Main Authors: Srinivasan, S.R, Ehnholm, C, Wattigney, W.A, Berenson, G.S
• Format: Journal Article
• Language: English
• Published: United States 01.04.1994
• Subjects: Adolescent; Alleles; apolipoproteins; Apolipoproteins E - genetics; blood serum; body fat; Child; children; Female; Gene Frequency; Humans; lipoproteins; Lipoproteins - blood; Male; obesity; Obesity - blood; Obesity - genetics; Phenotype
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/0026-0495(94)90079-5

The influence of apolipoprotein (apo) E polymorphism on the association between body fatness and concentrations of serum lipoprotein variables was studied in a random subsample (n = 892) of 8- to 17-year-old children from a total community. Covariates (age, race, and sex)-adjusted mean values of percent body fat, ponderal index (wt/ht3), and subscapular skinfold thickness differed significantly among apo E phenotype groups, with the apo E2 group (n = 61) carrying E2/2 and E3/2 phenotypes having significantly (P < .01) lower values than the apo E3 group (n = 480) carrying the E3/3 phenotype. In the apo E3 group, covariates-adjusted partial correlation coefficients showed significant (P < .05 to P < .001) associations between obesity measures and lipoprotein variables studied that are generally seen in populations. However, these associations, with the exception of low-density lipoprotein (LDL) cholesterol and apo B, were altered in the other apo E phenotype groups. In the apo E2 group, obesity measures correlated significantly with triglycerides (P < .05 to P < .001), but not with very-low-density lipoprotein (VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and apo A-I. In contrast, in the apo E4 group (n = 212) carrying E4/3 and E4/4 phenotypes, obesity measures correlated significantly with HDL cholesterol (P < .05 to P < .001) and apo A-I (P < .01), but not with triglycerides and VLDL cholesterol. Therefore, the apo E phenotype should be taken into account in the association between body fatness and serum lipoproteins.