National surveillance of antimicrobial susceptibilities to ceftaroline, dalbavancin, telavancin, tedizolid, eravacycline, omadacycline, and other comparator antibiotics, and genetic characteristics of bacteremic Staphylococcus aureus isolates in adults: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) program in 2020

• Published in: International journal of antimicrobial agents Vol. 61; no. 4; p. 106745
• Main Authors: Chen, Chih-Hao, Wu, Pin-Han, Lu, Min-Chi, Ho, Mao-Wang, Hsueh, Po-Ren
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2023
• Subjects: Adult; Aged; Anti-Bacterial Agents - pharmacology; antibiotic resistance; automation; bacteremia; Bacteremia - drug therapy; blood flow; Ceftaroline; chromosomes; Community-Acquired Infections - epidemiology; Cross Infection - epidemiology; dalbavancin; Daptomycin; demographic statistics; Drug Resistance, Bacterial; Eravacycline; Humans; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; monitoring; Omadacycline; Panton-Valentine leukocidin; polymerase chain reaction; Staphylococcal cassette chromosome mec; Staphylococcal Infections - drug therapy; Staphylococcal Infections - epidemiology; Staphylococcus aureus; Taiwan; Tedizolid; Telavancin; Taiwan; Panton-Valentine leukocidin; Eravacycline; Telavancin; Staphylococcal cassette chromosome mec; Methicillin-resistant Staphylococcus aureus; Ceftaroline; Daptomycin; Omadacycline; Tedizolid
• ISSN: 0924-8579; 1872-7913; 1872-7913
• DOI: 10.1016/j.ijantimicag.2023.106745

•In 2020, 315 Staphylococcus aureus (145 MSSA, 170 MRSA) isolates from 16 hospitals in Taiwan were evaluated.•MIC50/MIC90 values of eravacycline and omadacycline were 0.06/0.12, and 0.25/0.5, respectively.•4.1% of MRSA isolates showed susceptible dose-dependence to ceftaroline; 85.7% of these were HAI- and PVL-negative.•7.1% of MRSA isolates were non-susceptible to telavancin and tedizolid, 0.6% to daptomycin and 1.8% to quinupristin/dalfopristin.•All MRSA isolates were susceptible to dalbavancin. Methicillin-resistant Staphylococcus aureus (MRSA) causes invasive infections and is associated with community-acquired infections (CAIs) and hospital-associated infections (HAIs). In 2020, 315 S. aureus isolates, including 145 methicillin-susceptible S. aureus (MSSA) and 170 MRSA, mainly associated with bacteremia and mostly CAIs, were collected from 16 hospitals in different regions of Taiwan. Minimum inhibitory concentrations (MICs) were determined using the Sensititre™ complete automated AST system. Staphylococcal cassette chromosome mec (SCCmec) types were analysed using multiplex polymerase chain reaction. The median age of patients infected with MRSA was significantly higher than that of patients infected with MSSA (72.5 years vs. 67.0 years, P=0.027). MIC50/MIC90 values of eravacycline and omadacycline were 0.06/0.12, and 0.25/0.5, respectively. Of the MRSA isolates, 4.1% presented susceptible dose-dependence to ceftaroline, most of which (85.7%) were HAI- and Panton-Valentine leukocidin (PVL)-negative. Among the MRSA isolates, 7.1% were not susceptible to telavancin and tedizolid (mainly type IV, PVL-negative, and CAI), 0.6% were not susceptible to daptomycin (type III, PVL-negative, and HAI), and 1.8% were not susceptible to quinupristin/dalfopristin (three isolates were type III, IV, and VT, respectively, and all were PVL-negative), but all were susceptible to dalbavancin. In conclusion, patients with bacteremia caused by MRSA were older than those with bacteremia caused by MSSA, SCCmec type IV was more predominant in CAI than in HAI, and MRSA isolates not susceptible to novel anti-MRSA antimicrobials belonged to types II, III, or IV. Further studies that include comprehensive demographics and more detailed descriptions of other antimicrobial-resistant genes are urgently needed.