Tacrolimus for Treating Orbital and Cranial Form of Idiopathic Inflammatory Pseudotumors
BACKGROUND AND PURPOSEOrbital and cranial form of idiopathic inflammatory pseudotumors (IIPs) are rare disorders with heterogeneous clinical presentations. Corticosteroids have been the first-line treatment for IIPs, but they are not always effective. METHODSWe reviewed the medical records of three...
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Published in | Journal of clinical neurology (Seoul, Korea) Vol. 16; no. 4; pp. 674 - 680 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korean Neurological Association
01.10.2020
대한신경과학회 |
Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND AND PURPOSEOrbital and cranial form of idiopathic inflammatory pseudotumors (IIPs) are rare disorders with heterogeneous clinical presentations. Corticosteroids have been the first-line treatment for IIPs, but they are not always effective. METHODSWe reviewed the medical records of three patients with orbital or cranial form of IIP who were treated with tacrolimus as an adjuvant treatment. RESULTSThe three patients showed favorable outcomes with the addition of tacrolimus, which is a calcineurin inhibitor that inhibits T-cell activation and T-cell-dependent B-cell activation. CONCLUSIONSTacrolimus may be a safe and effective immunosuppressant for refractory or relapsing form of orbital or cranial IIPs. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 https://doi.org/10.3988/jcn.2020.16.4.674 |
ISSN: | 1738-6586 2005-5013 |
DOI: | 10.3988/jcn.2020.16.4.674 |