Trace metal imbalance associated with oxidative stress and inflammatory status in anti-hepatitis C virus antibody positive subjects

Highlights ► Anti-HCV-positive individuals had lower plasma zinc, and higher copper, iron, lead, cadmium, and aluminum concentrations. ► Anti-HCV-positive had an imbalance of pro-oxidant/anti-oxidant system and inflammatory processes. ► Interactions between toxic and essential metals may further con...

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Bibliographic Details
Published inEnvironmental toxicology and pharmacology Vol. 33; no. 2; pp. 288 - 296
Main Authors Guo, Chih-Hung, Chen, Pei-Chung, Lin, Kuan-Pin, Shih, Min-Yi, Ko, Wang-Sheng
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2012
Subjects
Anti-HCV
Biomarkers - blood
Case-Control Studies
Emergency
Enzymes - blood
Female
Hepacivirus - immunology
Hepatitis B - blood
Hepatitis B - diagnosis
Hepatitis C Antibodies - blood
Humans
Inflammation
Inflammation Mediators - blood
Lipid Peroxidation
Male
Metals - blood
Middle Aged
Oxidative Stress
Taiwan
Trace Elements - blood
Trace metals
Taiwan
Oxidative stress
Anti-HCV
Inflammation
Trace metals
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Summary:Highlights ► Anti-HCV-positive individuals had lower plasma zinc, and higher copper, iron, lead, cadmium, and aluminum concentrations. ► Anti-HCV-positive had an imbalance of pro-oxidant/anti-oxidant system and inflammatory processes. ► Interactions between toxic and essential metals may further contribute to oxidative damage and inflammation.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2011.12.018