Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese

• Published in: Disease markers Vol. 24; no. 3; pp. 167 - 173
• Main Authors: Wong, Louisa Y F, Ong, Kwok Leung, Cheung, Bernard M Y, Leung, Raymond Y H, Man, Yu Bun, Lam, Tai Hing
• Format: Journal Article
• Language: English
• Published: United States IOS Press 2008
• Subjects: Adult; Blood Glucose - analysis; Female; Fibrinogen - genetics; Genotype; Glucose Tolerance Test; Hong Kong; Humans; Male; Middle Aged; Other; Polymorphism, Single Nucleotide; Regression Analysis; Hong Kong
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2008/951894

Fibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-beta gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 +/- 0.65 vs 2.42 +/- 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 +/- 1.14 vs 5.47 +/- 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance.