Antiatherosclerotic Effect and Molecular Mechanism of Salidroside

Atherosclerotic cardiovascular disease is currently the leading cause of death worldwide. Its pathophysiological basis includes endothelial dysfunction, macrophage activation, vascular smooth muscle cell (VSMC) proliferation, lipid metabolism, platelet aggregation, and changes in the gut microbiota....

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Published inReviews in cardiovascular medicine Vol. 24; no. 4; p. 97
Main Authors Fei, Si-Fan, Tong, De-Bing, Jia, Fang
Format Journal Article
LanguageEnglish
Published Singapore IMR Press 01.04.2023
Subjects
atherosclerosis
cell targets
endothelial dysfunction
gut microbiota
lipid metabolism
Review
salidroside
atherosclerosis
cell targets
salidroside
endothelial dysfunction
gut microbiota
lipid metabolism
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Summary:Atherosclerotic cardiovascular disease is currently the leading cause of death worldwide. Its pathophysiological basis includes endothelial dysfunction, macrophage activation, vascular smooth muscle cell (VSMC) proliferation, lipid metabolism, platelet aggregation, and changes in the gut microbiota. Salidroside has beneficial effects on atherosclerosis through multiple pathways. In this review, we present studies on the regulatory effect of salidroside on atherosclerosis. Furthermore, we report the protective effects of salidroside against atherosclerosis by ameliorating endothelial dysfunction, suppressing macrophage activation and polarization, inhibiting VSMC proliferation, adjusting lipid metabolism, attenuating platelet aggregation, and modulating the gut microbiota. This review provides further understanding of the molecular mechanism of salidroside and new ideas for atherosclerosis management.
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These authors contributed equally.
ISSN:1530-6550
2153-8174
1530-6550
DOI:10.31083/j.rcm2404097