Recent Advances on Electrochemical Biosensing Strategies toward Universal Point‐of‐Care Systems

• Published in: Angewandte Chemie International Edition Vol. 58; no. 36; pp. 12355 - 12368
• Main Authors: Dai, Yifan, Liu, Chung Chiun
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 02.09.2019
• Edition: International ed. in English
• Subjects: analytical electrochemistry; biosensing; Biosensors; Electrochemistry; Fabrication; Industrial development; Nucleic acids; point-of-care; Sensitivity analysis; universal biosensors; biosensing; analytical electrochemistry; point-of-care; universal biosensors
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201901879

A number of very recently developed electrochemical biosensing strategies are promoting electrochemical biosensing systems into practical point‐of‐care applications. The focus of research endeavors has transferred from detection of a specific analyte to the development of general biosensing strategies that can be applied for a single category of analytes, such as nucleic acids, proteins, and cells. In this Minireview, recent cutting‐edge research on electrochemical biosensing strategies are described. These developments resolved critical challenges regarding the application of electrochemical biosensors to practical point‐of‐care systems, such as rapid readout, simple biosensor fabrication method, ultra‐high detection sensitivity, direct analysis in a complex biological matrix, and multiplexed target analysis. This Minireview provides general guidelines both for scientists in the biosensing research community and for the biosensor industry on development of point‐of‐care system, benefiting global healthcare. Making good biosense: Recent cutting‐edge research on electrochemical biosensing strategies are described. These developments resolved critical challenges regarding the application of electrochemical biosensors to practical point‐of‐care systems, such as rapid readout, simple biosensor fabrication methods, ultra‐high detection sensitivity, direct analysis in a complex biological matrix, and multiplexed target analysis.