Interleukin-2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates

• Published in: FEBS letters Vol. 220; no. 1; pp. 52 - 56
• Main Authors: Wickremasinghe, R.Gitendra, Mire-Sluis, Anthony R., Hoffbrand, A.Victor
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10.08.1987; Elsevier
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Binding Sites; Biological and medical sciences; Cyclic AMP - metabolism; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Growth factor; Humans; Immunobiology; Inositol lipid; Inositol Phosphates - metabolism; Interleukin-2 - physiology; Lymphocyte Activation; Lymphokine; Organs and cells involved in the immune response; Phytohemagglutinins - pharmacology; Protein phosphorylation; Second messenger; Sugar Phosphates - metabolism; T-Lymphocytes - metabolism; Lymphokine; Protein phosphorylation; Inositol lipid; Second messenger; Growth factor; Cell proliferation; Phosphorylation; Calcium; Cyclic AMP; Cellular immunity; Immune regulation; Phosphate sugar; Biological activity; Proteins; Signal transduction; Membrane receptor; Interleukin 2; T-Lymphocyte
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(87)80874-8

Human T lymphocytes stimulated with phytohaemagglutinin undergo a single round of cell division. Further proliferation is dependent on the lymphokine interleukin-2 (IL2) [(1987) Immunology 60, 7–12]. We show here that binding of IL2 to its receptors on the lymphocyte surface triggers the generation of cyclic AMP. In contrast, generation of inositol phosphates from the breakdown of inositol lipids was not detected. We suggest that cyclic AMP may play a role in the transduction of the IL2 proliferative signal in T lymphocytes.