Visible‐Light‐Promoted Cascade Radical Cyclization: Synthesis of 1,4‐Diketones Containing Chroman‐4‐One Skeletons

• Published in: Chemistry, an Asian journal Vol. 14; no. 19; pp. 3269 - 3273
• Main Authors: He, Xiang‐Kui, Cai, Bao‐Gui, Yang, Qing‐Qing, Wang, Long, Xuan, Jun
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2019
• Subjects: 1,4-Diketones; Acyl radical; Benzaldehyde; Chemistry; Diketones; Photoredox catalysis; Radical cyclization; Synthesis; Visible light; Photoredox catalysis; Radical cyclization; Visible light; Acyl radical; 1,4-Diketones
• ISSN: 1861-4728; 1861-471X; 1861-471X
• DOI: 10.1002/asia.201901078

A visible‐light‐induced cascade radical cyclization of aroyl chlorides with 2‐(allyloxy)‐benzaldehyde derivatives has been developed. The method takes advantages of unactivated C=C bonds as the acyl radical acceptors and offers a mild and green approach for the synthesis of 1,4‐diketones bearing biologically important chroman‐4‐one skeletons with moderate to good yields. A visible‐light‐induced cascade radical cyclization of aroyl chlorides with 2‐(allyloxy)‐benzaldehyde derivatives has been developed. The method takes advantage of unactivated C=C bonds as the acyl radical acceptors and offers a mild and green approach for the synthesis of 1,4‐diketones bearing biologically important chroman‐4‐one skeletons in moderate to good yields.