Estrogen receptors in hepatocellular carcinoma

Estrogen receptors (ER) were assayed on hepatocellular carcinoma (HCC) and surrounding liver tissue in 30 adult patients. All specimens were obtained at the time of surgery. Cirrhosis of the liver was associated with 28 patients and chronic hepatitis in 2 patients. ERs were detected in 12 of 30 HCCs...

Full description

Saved in:
Bibliographic Details
Published inCancer Vol. 57; no. 1; pp. 87 - 91
Main Authors Nagasue, Naofumi, Yukaya, Hirofumi, Ogawa, Yuichiro, Ito, Akio
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.01.1986
Wiley-Liss
Subjects
Aged
Biological and medical sciences
Carcinoma, Hepatocellular - analysis
Cytosol - analysis
Estrogens - adverse effects
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis - metabolism
Humans
Liver - analysis
Liver Cirrhosis - metabolism
Liver Neoplasms - analysis
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Receptors, Estrogen - analysis
Tumors
Human
Pathology
Liver cell carcinoma
Liver
Tumoral tissue
Estrogen
Digestive diseases
Tumor
Hepatobiliary disease
Hormonal receptor
Online AccessGet full text

Cover

More Information
Summary:Estrogen receptors (ER) were assayed on hepatocellular carcinoma (HCC) and surrounding liver tissue in 30 adult patients. All specimens were obtained at the time of surgery. Cirrhosis of the liver was associated with 28 patients and chronic hepatitis in 2 patients. ERs were detected in 12 of 30 HCCs. The value ranged from 1.4 to 9.2 fmol/mg cytosol protein with the dissociation constant (Kd) value less than 1 nanomol. On the other hand, 13 of 28 cirrhotic livers had measurable amounts of the receptors that ranged from 1.5 to 4.1 fmol/mg cytosol protein. Two livers with chronic hepatitis did not have detectable amounts of ERs. The receptors were not detected in both the tumor and liver in ten patients. The ER titers in HCC did not have any correlation with serum levels of α‐fetoprotein or carcinoembryonic antigen, hepatitis B virus profils, and histologic types of the tumor. In the light of the current results, it would be of great interest whether hormone therapy can be used or not as a treatment of naturally occurring HCC in humans.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19860101)57:1<87::AID-CNCR2820570118>3.0.CO;2-K