Cartilage repair with autogenic perichondrium cell/polylactic acid grafts: A two-year study in rabbits

The repair of articular cartilage injuries remains a challenge. In this 2‐year study, osteochondral defects in the femoral condyles of five rabbits were repaired with an autogenic perichondrium cell/polylactic acid grafts and compared with a contralateral control in which the defect remained empty....

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Published inJournal of orthopaedic research Vol. 18; no. 3; pp. 512 - 515
Main Authors Dounchis, Jon S., Coutts, Richard D., Amiel, David
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2000
Subjects
Animals
Cartilage
Cartilage, Articular - pathology
Cartilage, Articular - physiology
Cartilage, Articular - surgery
Cell Transplantation
Cytology
Femur - surgery
Grafts
Lactic Acid
Living systems studies
Polyesters
Polymers
Rabbits
Transplantation, Autologous
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Summary:The repair of articular cartilage injuries remains a challenge. In this 2‐year study, osteochondral defects in the femoral condyles of five rabbits were repaired with an autogenic perichondrium cell/polylactic acid grafts and compared with a contralateral control in which the defect remained empty. The rabbits in the group with the grafts had a higher percentage of biologically acceptable repairs (100%) than did those in the control group (80%). According to the histologic and histomorphometric analyses, the grafts augmented the intrinsic healing. Nonetheless, the results for the grafts were tarnished by a depressed repair surface and a histologic appearance not equivalent to that of normal cartilage. The application of growth factors to this model may yield a clinical treatment.
Bibliography:istex:C759BAB88CEF98CFC487AC707DD7B3FDA74E2AE5
ark:/67375/WNG-JKL2MJK4-Q
ArticleID:JOR1100180327
ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0736-0266
1554-527X
DOI:10.1002/jor.1100180327