Inhibitors of biotin biosynthesis as potential herbicides: Part 2
Isosteres and analogues of 7‐keto‐8‐aminopelargonic acid (KAPA) and 7,8‐diaminopelargonic acid (DAPA), the vitamer intermediates involved in the biosynthetic pathway of biotin, possessing chain lengths of eight carbon atoms, were prepared and evaluated as potential herbicides. The most active compou...
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Published in | Pest management science Vol. 61; no. 10; pp. 1024 - 1033 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.10.2005
Wiley Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Isosteres and analogues of 7‐keto‐8‐aminopelargonic acid (KAPA) and 7,8‐diaminopelargonic acid (DAPA), the vitamer intermediates involved in the biosynthetic pathway of biotin, possessing chain lengths of eight carbon atoms, were prepared and evaluated as potential herbicides. The most active compounds, 7‐amino‐octanoic acid hydrochloride and 7‐allyloxy‐6‐oxo‐octanoic acid, displayed Arabidopsis GR50 (concentration of the active compound that causes a 50% growth inhibition) values of 5 and 10 mg kg−1 respectively. The DAPA analog 6,7‐diamino‐octanoic acid dihydrochloride, when tested in the greenhouse against six weed species, displayed moderate activity against three species, being most active against foxtail millet. Copyright © 2005 Society of Chemical Industry |
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Bibliography: | ark:/67375/WNG-TPPDGS4C-N istex:489FFBFEE057F80A8A5B3E904F4AB4EB813DFBE3 ArticleID:PS1075 Part 1: Nudelman A, Marcovici-Mizrahi D, Flint D and Wittenbach V, Inhibitors of biotin biosynthesis as potential herbicides. Tetrahedron 60:1731-1748 (2004) Marcus Centre for Pharmaceutical and Medicinal Chemistry, Bar Ilan University 1731–1748 (2004) 60 Tetrahedron Part 1: Nudelman A, Marcovici‐Mizrahi D, Flint D and Wittenbach V, Inhibitors of biotin biosynthesis as potential herbicides. |
ISSN: | 1526-498X 1526-4998 |
DOI: | 10.1002/ps.1075 |