Structure, Immunogenicity, and Protectivity Relationship for the 1585 Malarial Peptide and Its Substitution Analogues
Rational design of a malaria vaccine may result from the structure–immunogenicity relationship of analogues of peptide 1585, a protein sequence located at the N‐terminal end of the P. falciparum 42‐kDa merozoite surface protein‐1. Altering a few amino acids in peptide 1585 (left) induces immunogenic...
Saved in:
Published in | Angewandte Chemie (International ed.) Vol. 40; no. 24; pp. 4654 - 4657 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag GmbH
17.12.2001
WILEY‐VCH Verlag GmbH |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Rational design of a malaria vaccine may result from the structure–immunogenicity relationship of analogues of peptide 1585, a protein sequence located at the N‐terminal end of the P. falciparum 42‐kDa merozoite surface protein‐1. Altering a few amino acids in peptide 1585 (left) induces immunogenicity and protectivity, and changes the 3D structure, as shown for one of the analogues synthesized (right). |
---|---|
Bibliography: | ArticleID:ANIE4654 ark:/67375/WNG-MKLH639R-8 istex:35EBCC60AD8E2CEBC5E13AD6206F3725B7B3E1F2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/1521-3773(20011217)40:24<4654::AID-ANIE4654>3.0.CO;2-F |