Structure, Immunogenicity, and Protectivity Relationship for the 1585 Malarial Peptide and Its Substitution Analogues

Rational design of a malaria vaccine may result from the structure–immunogenicity relationship of analogues of peptide 1585, a protein sequence located at the N‐terminal end of the P. falciparum 42‐kDa merozoite surface protein‐1. Altering a few amino acids in peptide 1585 (left) induces immunogenic...

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Published inAngewandte Chemie (International ed.) Vol. 40; no. 24; pp. 4654 - 4657
Main Authors Espejo, Fabiola, Cubillos, Marcia, Salazar, Luz Mary, Guzman, Fanny, Urquiza, Mauricio, Ocampo, Marisol, Silva, Yolanda, Rodriguez, Raul, Lioy, Eduardo, Patarroyo, Manuel Elkin
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 17.12.2001
WILEY‐VCH Verlag GmbH
Subjects
immunochemistry
malaria
NMR spectroscopy
protein modification
protein structures
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Summary:Rational design of a malaria vaccine may result from the structure–immunogenicity relationship of analogues of peptide 1585, a protein sequence located at the N‐terminal end of the P. falciparum 42‐kDa merozoite surface protein‐1. Altering a few amino acids in peptide 1585 (left) induces immunogenicity and protectivity, and changes the 3D structure, as shown for one of the analogues synthesized (right).
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ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20011217)40:24<4654::AID-ANIE4654>3.0.CO;2-F